Anastrozole
What it is
Anastrozole is an aromatase inhibitor that reduces the conversion of testosterone to estradiol. In men's hormone therapy it is used selectively, and only where laboratory findings and symptoms together indicate it.
How it is used
Taken orally at low doses on a schedule set by the prescriber. Contemporary practice uses it more sparingly than was once common, because estradiol has necessary functions in men — including bone density, lipids and libido — and over-suppression causes its own problems.
What a provider evaluates first
- Measured estradiol using an appropriate assay, alongside symptoms
- Whether dose or interval adjustment would address the issue first
- Bone density risk factors
Considerations and monitoring
- Not routinely required for testosterone therapy
- Over-suppression of estradiol carries its own risks
- Used only where clinically indicated, and reviewed at each follow-up
Questions about anastrozole
Do I need an aromatase inhibitor on testosterone therapy?
Usually not. Aromatase inhibitors such as anastrozole are used selectively, where measured estradiol and symptoms together indicate it. Estradiol has necessary functions in men, including in bone density, lipids and libido, so over-suppression causes its own problems. Adjusting testosterone dose or interval is often considered before adding one.
Part of TRT & Men's Health.