Testosterone cypionate
Also known as Depo-Testosterone
What it is
Testosterone cypionate is an injectable ester of testosterone with a long half-life, typically administered weekly or twice weekly. It is the most widely used form of testosterone replacement in the United States.
How it is used
It is given by subcutaneous or intramuscular injection on a schedule set by the prescribing provider. Because the ester releases slowly, dosing frequency affects how stable levels remain between injections. Providers commonly split a weekly dose across two administrations to reduce peaks and troughs.
What a provider evaluates first
- Baseline total and free testosterone, confirmed on more than one draw
- Haematocrit, which testosterone can raise and which is monitored throughout
- Fertility intentions, since testosterone suppresses sperm production
- Cardiovascular history, blood pressure and sleep apnoea
- PSA where age-appropriate
Considerations and monitoring
- Requires ongoing laboratory monitoring, not a one-time prescription
- Suppresses the body's own testosterone production and spermatogenesis
- May raise haematocrit; periodic bloodwork exists to detect this
- Site reactions and mood or libido changes are reported and should be raised with your provider
Testosterone is a Schedule III controlled substance in the United States. Prescribing requires a synchronous consultation with a licensed provider.
Questions about testosterone cypionate
How often do you inject testosterone cypionate?
Dosing schedules are set by the prescribing provider. Testosterone cypionate is long-acting, and weekly or twice-weekly administration are both common. Splitting a weekly dose across two injections is often used to reduce the peak-and-trough swing between doses.
Subcutaneous or intramuscular testosterone injection?
Both routes are used. Subcutaneous injection uses a shorter, finer needle and is often reported as more comfortable and easier to self-administer; intramuscular is the longer-established route. Which is recommended depends on your provider's protocol, your dose and your own preference. Injection technique is covered as part of onboarding.
Does testosterone therapy affect fertility?
Yes. Exogenous testosterone suppresses the hormonal signals that drive sperm production, and this can reduce or halt spermatogenesis while on therapy. If you intend to conceive now or in future, raise it before starting. Providers may consider alternatives such as enclomiphene, which raises endogenous testosterone without the same suppressive effect, or adjunct protocols alongside testosterone.
Part of TRT & Men's Health.